Supplementation Protocol

Supplementation Protocol

← Go back

Supplementation Protocol

image

Goals

  1. Maximize functional recovery within biological constraints
  2. Prevent secondary neurodegeneration
  3. Optimize neural tissue function
  4. Manage ADHD while supporting brain repair

Framework

Pillar 1: Neuroprotection

  • Primary agents: NAC (1200mg), Omega-3s (EPA 3000mg)
  • Supporting agents: Theracurmin, Vitamin E (in omega-3s)
  • Mechanism: Glutathione replenishment, anti-inflammatory cascades

Pillar 2: Neuroplasticity Enhancement

  • Primary agents: Lion's Mane (3000mg), CDP-Choline (1000mg), DHA (1000mg)
  • Supporting agents: PQQ, NR+Resveratrol
  • Mechanism: NGF/BDNF stimulation, membrane synthesis, mitochondrial biogenesis

Pillar 3: Metabolic Support

  • Primary agents: Creatine (5g), Ca-AKG (2000mg)
  • Supporting agents: B-complex, CoQ10 (via PQQ pathway)
  • Mechanism: ATP maintenance, Krebs cycle optimization

Prioritization

Tier 1: Strong Clinical Evidence

  1. NAC 1200mg - Military TBI protocol, 86% symptom improvement
  2. Omega-3 (EPA 3000mg + DHA 1000mg) - Multiple RCTs, 30% perfusion improvement
  3. Creatine 5g - Pediatric TBI studies, significant cognitive gains
  4. CDP-Choline 1000mg - Meta-analysis showing 18% functional independence increase

Tier 2: Moderate Evidenced

  1. Lion's Mane 3000mg - Mori et al. RCT in MCI, NGF stimulation proven
  2. Phosphatidylserine 600mg - Membrane repair, cortisol modulation
  3. Sulforaphane 35mg - Animal TBI models, human autism/schizophrenia benefits
  4. Magnesium Glycinate 200mg - NMDA modulation, sleep architecture

Tier 3: Theoretical/Emerging

  1. Ca-AKG 2000mg - Mitochondrial support, no direct TBI evidence
  2. PQQ 20mg - Mitochondrial biogenesis, limited human data
  3. Spermidine 10mg - Autophagy induction, one positive human trial
  4. NR + Resveratrol - NAD+ support, general neuroprotection

Timing

Empty Stomach (optimal absorption):

  • NAC, PQQ, Sulforaphane, Ca-AKG
  • 30-minute window before meals

With Meals (fat-soluble/GI protection):

  • All fat-soluble vitamins (D3, K, E)
  • Phospholipids (PS, CDP-Choline)
  • Omega-3s (enhanced absorption with fats)

Circadian Alignment:

  • Stimulating compounds (morning): PQQ, B-complex
  • Neutral compounds (both): Most supplements
  • Calming compounds (evening): Magnesium, Lithium, Melatonin

Interactions

  • Concerta compatibility: All supplements verified safe
  • Anticoagulation monitoring: Multiple mild antiplatelet effects
  • Liver burden distributed: 41 pills across 5 timing windows

Quality

Premium Suppliers Selected

  • Nootropics Depot: Lion's Mane (8:1 standardized extract)
  • Jarrow Formulas: BroccoMax (myrosinase-activated), CDP-Choline
  • Life Extension: PQQ, Super K, Lithium
  • NOW Foods: DHA-500, NAC, Magnesium

Monitoring

Biomarker Tracking

Baseline (immediate):

  • CBC, CMP, Lipid panel
  • Omega-3 Index
  • Vitamin D levels
  • Liver enzymes (AST, ALT, GGT)

Monthly:

  • Liver function (high supplement load)
  • Executive function assessment (MoCA or similar)

Quarterly:

  • Full panel repeat
  • Omega-3 Index (target >8%)
  • Inflammatory markers (CRP, IL-6)

Sustainability

Year 1: Intensive Repair

  • Full protocol as designed
  • Monthly monitoring
  • Quarterly adjustments based on response

Year 2: Optimization

  • Reduce experimental supplements if no clear benefit
  • Maintain core interventions (NAC, Omega-3, Creatine, Lion's Mane)
  • Consider prescription additions (Memantine)

Lifetime Maintenance

Forever required:

  • Omega-3s (EPA+DHA)
  • Magnesium
  • Basic antioxidant support
  • ADHD medication

Cyclical:

  • Lion's Mane (quarterly cycles)
  • Intensive protocols (annually)

Risk Management

Safety Profile

  • No dangerous drug interactions identified
  • Bleeding risk from antiplatelet stack (monitor)
  • Liver processing of 41 daily compounds (monitor enzymes)
  • GI tolerance (split dosing helps)

Failure Points Addressed

  • Product quality verified
  • Dosing corrected to therapeutic levels
  • Timing optimized for absorption
  • Compliance supported by organization system

Rationale

This protocol represents a systematic, evidence-based approach to maximizing functional c ognition. By addressing oxidative stress (NAC), inflammation (EPA), structural repair (DHA, PS), neuroplasticity (Lion's Mane), and metabolic support (Creatine, Ca-AKG), we create multiple synergistic pathways for compensation and adaptation.

The protocol prioritizes interventions with human clinical evidence, while cautiously including theoretical agents with strong mechanistic rationale and minimal risk. Cost-effectiveness has been optimized by eliminating ineffective products and ensuring therapeutic dosing of proven interventions.

Expected outcomes are realistic: 60-70% functional improvement represents the upper boundary of what's achievable with supplementation. However, for a 34-year-old with significant functional impairment, this degree of improvement could be life-changing.

Daily Schedule:

Morning Routine:

Step 1 - Empty Stomach:

  • NAC - 1 capsule (600mg)
  • PQQ - 1 capsule (20mg)
  • BroccoMax - 1 capsule (17.5mg SGS)
  • Ca-AKG - 2 capsules (1000mg)
  • Creatine - 5g powder in water
  • Inulin - 1 tsp powder (3.3g)

Wait 30 minutes

Step 2 - With Breakfast:

  • Concerta - 54mg
  • Lion's Mane - 3 capsules (1500mg)
  • CDP-Choline - 3 capsules (750mg)
  • Phosphatidylserine - 2 capsules (300mg)
  • Omega-3 EPA - 3 softgels (1500mg EPA)
  • DHA-500 - 1 softgel (500mg DHA + 250mg EPA)
  • Theracurmin - 1 capsule (300mg)
  • Vitamin D3 - 1 softgel (2000 IU)
  • Zeaxanthin/Lutein - 1 softgel
  • B-Complex - 0.25 pill daily
  • B12 methylcobalamin - 1x/wk
  • NR + Resveratrol - 2 capsules (500mg NR + 150mg Resveratrol)

Evening Routine:

Step 1 - Empty Stomach:

  • NAC - 1 capsule (600mg)
  • Ca-AKG - 2 capsules (1000mg)
  • BroccoMax - 1 capsule (17.5mg SGS)
  • Zinc - 1 capsule (15mg)
  • Copper (glycinate) - 1 capsule (2 mg)

Wait 30 minutes

Step 2 - With Dinner:

  • Lion's Mane - 3 capsules (1500mg)
  • Super K - 1 softgel
  • CDP-Choline - 3 capsules (750mg)
  • Phosphatidylserine - 2 capsules (300mg)
  • Omega-3 EPA - 2 softgels (1000mg EPA)
  • DHA-500 - 1 softgel (500mg DHA + 250mg EPA)
  • Theracurmin - 1 capsule (300mg)
  • Kyolic Garlic - 2 capsules (600mg)
  • Spermidine - 2 capsules (10mg)

Step 3 - Before Bed:

  • Lithium - 1 capsule (1mg)
  • Magnesium Glycinate - 2 tablets (200mg)
  • Melatonin Quiet Sleep - 1 capsule (5mg)

Daily Totals Summary:

Achieved Therapeutic Doses:

  • EPA: 3000mg ✓ (optimal for TBI)
  • DHA: 1000mg ✓
  • NAC: 1200mg ✓
  • Lion's Mane: 3000mg ✓ (8:1 extract)
  • CDP-Choline: 1000mg ✓
  • Phosphatidylserine: 600mg ✓
  • Sulforaphane: 35mg SGS ✓ (from BroccoMax)
  • Ca-AKG: 2000mg ✓
  • CDP-Choline: 1500mg ✓ (Safe enhancement of existing cholinergic support)
‣

Advanced details